SSN3 — Saccharomyces cerevisiae S288c

Summary

YPL042C, also known as SSN3, encodes a cyclin-dependent kinase (CDK) with RNA polymerase II CTD heptapeptide repeat kinase activity, protein serine/threonine kinase activity, and ATP binding. It is a component of the mediator complex and the serine/threonine protein kinase complex, localizing to the nucleus. SSN3 is associated with numerous biological processes including non-stop decay, response to host iron concentration, cellular response to carbon dioxide, the glucose effect, invasive growth, replicative senescence, and the cell integrity MAPK cascade. The gene is linked to traits such as potassium concentration, oxidative stress, and acid sensitivity. Phenotypic associations include increased flocculation, decreased sporulation efficiency, altered chronological lifespan, decreased stress resistance, increased oxidative stress resistance, decreased vegetative growth, and abnormal lipid particle morphology. Related genes in other species link the family to 2.7.11.23 and 2.7.11.22 enzyme activities.