ALD6 — Saccharomyces cerevisiae S288c

Summary

YPL061W (ALD6) on chromosome XVI of Saccharomyces cerevisiae S288c encodes a cytosolic aldehyde dehydrogenase with NAD(P)+ activity, also annotated as betaine-aldehyde dehydrogenase (NAD+). The gene is associated with acetate, ATP, fatty acid, ethyl acetate, acetoin, 1-butanol and isobutanol anabolism, the pentose-phosphate shunt, mixed acid fermentation, valine and pentose breakdown, choline oxidation, alcohol metabolism, pH reduction and NO storage. It localises to the cytoplasm, cytosol, nucleus, mitochondrial lumen, Golgi complex and extracellular space. ALD6 is linked to increased autophagy, viability, chronological lifespan, hyperosmotic, oxidative and metal stress resistance, respiratory growth rate, and protein and RNA accumulation, alongside decreased fermentative and exponential-phase growth, acid pH resistance, carbon source utilisation, vegetative growth, competitive fitness and chemical compound accumulation. The family is related to aldehyde dehydrogenases in other species.