MYO2 — Saccharomyces cerevisiae S288c

Summary

YOR326W, also known as MYO2 in Saccharomyces cerevisiae S288c, encodes a protein with calcium-dependent ATPase activity, microfilament motor activity, and binding to calmodulin, F-actin, the Arp2/3 complex, and small GTPases. This gene is associated with actin nucleation, actin cable assembly, retrograde transport of actin filament bundles, organelle inheritance, distribution of mitochondria and vacuoles, exocytosis, vesicle transport along actin filaments, and cell cycle progression through G1 phase and M phase, including spindle assembly. The encoded protein localizes to the myosin complex, cortical cytoskeleton, and transport vesicles. YOR326W is associated with oxidative stress and phenotypes including abnormal actin cytoskeleton morphology, decreased cytokinesis, abnormal mitochondrial distribution, decreased viability, and altered resistance to heat, UV, acid pH, and chemicals.