HST2 — Saccharomyces cerevisiae S288c

Summary

YPL015C (HST2) on chromosome XVI of Saccharomyces cerevisiae S288c encodes a sirtuin family NAD-dependent histone deacetylase. The enzyme is annotated with NAD-dependent histone deacetylase activity at H3K9, H3K14, H4K16, and H3K4, as well as protein deacetylase activity and NAD+ binding. HST2 is associated with telomeric silencing, suppression of telomeric recombination, rDNA heterochromatin assembly, epigenetic regulation of gene expression, ribosome biogenesis, and rRNA processing. It is also linked to cellular response to oxygen levels, regulation of cell differentiation, and downregulation of mitotic recombination and meiosis. The protein localizes to chromatin, subtelomeric and centric heterochromatin, the SET3C complex, and the nucleus. Phenotypic associations include increased chronological lifespan and innate thermotolerance, decreased filamentous and invasive growth, and altered competitive fitness and chemical resistance.