RAD1 — Saccharomyces cerevisiae S288c

Summary

YPL022W in Saccharomyces cerevisiae S288c encodes a protein with 3' overhang single-stranded DNA endodeoxyribonuclease activity, single-stranded DNA endodeoxyribonuclease activity, and damaged DNA binding. It is a member of the XPF and ERCC4 domain families. The gene is associated with multiple DNA repair pathways including recombinational repair, base excision repair, nucleotide excision repair, mismatch repair, postreplication repair, and bypass DNA synthesis. It is also linked to chromatin silencing, mitotic recombination, gene conversion, double-strand break repair via single-strand annealing, meiotic heteroduplex formation, cell cycle checkpoint, and cell killing. Localization evidence connects the product to the nucleus, cytoplasm, mitotic spindle pole body, and NEF1 complex. Phenotypic associations include decreased UV and X-ray resistance, altered mutation frequency, increased mitotic recombination, decreased sporulation, increased chronological lifespan, and decreased oxidative stress resistance.