REV1 — Saccharomyces cerevisiae S288c

Summary

YOR346W (REV1) on chromosome XV of Saccharomyces cerevisiae S288c encodes a deoxycytidyl transferase and DNA-directed DNA polymerase with damaged DNA binding and metal binding activities. The protein contains BRCT, UmuC, and Rev1 C-terminal domains. REV1 is associated with mutagenic postreplication repair, bypass DNA synthesis, DNA damage checkpoint, and the SOS response. It is linked to somatic hypermutation of antibody genes, mismatch repair, homologous recombination, and resolution of recombination intermediates. Localization evidence links the gene to the nucleus, nucleolus, mitochondrial chromosome, and sites of double-strand breaks. The gene is associated with altered mutation frequency, decreased UV resistance, increased replicative lifespan, and both increased and decreased oxidative stress resistance. Related genes in other species link the family to DNA polymerase activity (EC 2.7.7.-).