SEC63 — Saccharomyces cerevisiae S288c

Summary

YOR254C (SEC63) on chromosome XV of Saccharomyces cerevisiae S288c encodes a protein with protein transmembrane transporter activity and Hsp70 protein binding. The product contains a Sec63 domain and a DnaJ domain. SEC63 is associated with nuclear membrane fusion, microtubule-based movement, signal peptide processing, karyogamy, protein localization, protein secretion, protein import, SRP-dependent cotranslational membrane targeting, posttranslational protein targeting to ER membrane, protein transport, protein breakdown, membrane fusion, proteasome degradation, mitochondrial outer membrane protein import, secretion, endocytosis, receptor-mediated endocytosis, and vesicle transport. The protein localizes to the Sec62/63 complex, nuclear inner membrane, nuclear membrane-ER network, cortical ER, cell tip, cell division site, ER, mitochondria, and cytosol. Phenotypic associations include absent nuclear fusion during mating, decreased protein secretion, decreased mating efficiency, increased telomere length, decreased nucleolus size, abnormal mitochondrial morphology, increased heat sensitivity, decreased vegetative growth rate, and altered chemical resistance.