ESA1 — Saccharomyces cerevisiae S288c

Summary

YOR244W (ESA1) on chromosome XV of Saccharomyces cerevisiae S288c encodes a histone acetyltransferase with activity toward multiple histone residues, including H3K4 and H4K12, and functions as a peptide butyryltransferase, crotonyltransferase and 2-hydroxyisobutyryltransferase. The protein contains MYST-type HAT, Tudor-knot, zinc-finger MYST and chromo-like domains, and localises to the Piccolo histone acetyltransferase complex, nucleosomes, chromatin and the nucleus. ESA1 is associated with protein acetylation, regulation of DNA repair, telomeric silencing, chromatin modelling, rDNA heterochromatin assembly, positive regulation of triglyceride biosynthesis, phospholipid anabolism, glucose breakdown, stem cell renewal and organogenesis. Phenotypic associations include decreased telomere length, reduced silencing, delayed G1/S phase transition, decreased autophagy, increased heat sensitivity, reduced starvation resistance, altered RNA accumulation and localisation, and inviability.