WHI5 — Saccharomyces cerevisiae S288c

Summary

YOR083W, also known as WHI5 in Saccharomyces cerevisiae S288c, encodes a member of the Srl3/Whi5 protein family. The gene is associated with cell cycle control, including G1 phase progression, cell size regulation at the G1/S checkpoint, and the timing of START. It is linked to meiosis I, anaphase, M phase, S phase, and meiotic exit, as well as ribosome assembly and biogenesis, nuclear export, macroautophagy, and signal transduction. Phenotypic associations link YOR083W to altered cell size (both increased and decreased), changes in cell cycle phase durations, delayed exit from G0, increased replicative and chronological lifespan, reduced sporulation efficiency, abnormal cytoskeleton morphology, decreased UV resistance, and altered RNA and protein accumulation. The gene is also associated with phosphate and protein content, acid sensitivity, and oxidative stress.