MGM1 — Saccharomyces cerevisiae S288c

Summary

YOR211C in Saccharomyces cerevisiae S288c encodes a dynamin-family GTPase with membrane fusion GTPase activity, GTP binding, microtubule binding, and lipid binding. The gene is associated with mitochondrial fission and fusion, cristae formation, mitochondrial genome maintenance, and microtubule-mediated mitochondrion localization. It is linked to oxidative phosphorylation, quorum sensing, and vacuole fission. The protein localizes to mitochondrial membranes, microtubules, peroxisomes, and the cell division site. Phenotypic associations include decreased mitochondrial genome maintenance, abnormal mitochondrial morphology, increased biofilm formation, decreased respiratory growth, increased stress and metal resistance, decreased UV resistance, increased replicative lifespan, decreased chronological lifespan, and decreased vegetative growth. The gene is related to MGM1, and related genes in other species link the family to GTPase activity (EC 3.6.5.5).