STE4 — Saccharomyces cerevisiae S288c

Summary

YOR212W in Saccharomyces cerevisiae S288c encodes a protein with signaling receptor complex adaptor activity, dynein complex binding, transcription coactivator activity, and GTP binding. It is a member of the guanine nucleotide-binding protein beta subunit family, containing WD40 repeats. The gene is associated with heterotrimeric G-protein, TFIID, and SAGA complexes, and localizes to microtubules, spindle poles, the nucleolus, cytoplasm, cytosol, and nucleus. YOR212W is associated with nitric oxide signaling, retrotransposition, cell polarization, MAPK cascade, pheromone response, invasive and filamentous growth, GPCR signaling, and adenylyl cyclase activation. Phenotypic associations include altered mating response, shmoo formation, cell cycle progression, budding, cell size, vegetative growth, UV and metal resistance, and competitive fitness. Studies of related genes in other species link the family to reduced virulence.