PDR5 — Saccharomyces cerevisiae S288c

Summary

YOR153W (CDR1, PDR5) on chromosome XV of Saccharomyces cerevisiae S288c encodes an ABC transporter with phosphatidylethanolamine floppase, aminophospholipid flippase, and azole transmembrane transporter activities, also binding estradiol, corticosterone, and nucleotides. The gene is associated with cellular detoxification, response to doxorubicin and isooctane, TOR signaling, sterol, phospholipid, and sphingolipid anabolism, DNA metabolism and deamination, electron transport chain, immune system development, cell morphogenesis, and hormone and extracellular transport. It localizes to the plasma membrane, vacuolar lumen, and extracellular vesicles. Associations with oxidative stress and salt tolerance have been noted, along with phenotypes including altered growth rate, filamentous and invasive growth, chemical resistance, vacuolar morphology, and competitive fitness. Studies of related genes in other species link the family to unaffected pathogenicity.