HIS3 — Saccharomyces cerevisiae S288c
Summary
YOR202W in Saccharomyces cerevisiae S288c encodes imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19). The gene is associated with histidine anabolism and metabolism, as well as viral life cycle, SAGA complex assembly, transposition, lipid transport, nitrogen fixation, seed germination, and protein kinase A activation. It is linked to traits such as protein content, salt tolerance, and oxidative stress, and to phenotypes including auxotrophy, altered liquid culture appearance, decreased metal and chemical resistance, and increased chemical compound accumulation. Related genes in other species further connect the family to histidine biosynthesis.
Annotations
- Chromosome
- 15
- Related genes
- HIS3, ECM16, LEU2, FRT2, DBP5, ERG3, URA3, RPB3
- GO terms
- protein synthesis, Cell Growth, Biological_Process, Imidazoleglycerol-phosphate Dehydratase Activity, metal binding, Mating, vesicle transport, ergosterol anabolism
- Publications
- 28768829, 33524398, 28585565, 19659576, 28869701, 12684846, 25182531, 11779853
- Traits
- RESISTANCE TO CHEMICALS: DECREASED, COMPETITIVE FITNESS: DECREASED, STRESS RESISTANCE: DECREASED, INVIABLE, RESISTANCE TO CHEMICALS: INCREASED, RNA ACCUMULATION: INCREASED, INVASIVE GROWTH: INCREASED, RNA LOCALIZATION: ABNORMAL