RPB2 — Saccharomyces cerevisiae S288c

Summary

YOR151C, also known as RPB2, is a gene on chromosome XV of Saccharomyces cerevisiae S288c that encodes a protein with DNA-directed RNA polymerase activity, RNA binding, DNA binding, ribonucleoside binding, and zinc ion binding. The product is a component of RNA polymerase I, II, and III complexes and localizes to the nucleus, cytosol, mitochondria, and chromatin. RPB2 is associated with transcription initiation and elongation from RNA polymerase I and II promoters, RNA polymerase I and III transcription termination, chromatin remodeling, RNA interference-mediated heterochromatin assembly at centromeres, and global genome and transcription-coupled nucleotide excision repair. The gene is linked to increased cold sensitivity, decreased vegetative growth, altered osmotic stress resistance, reduced RNA accumulation, and changes in toxin and chemical resistance.