ADE2 — Saccharomyces cerevisiae S288c

Summary

YOR128C, also known as ADE2, encodes phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21), an enzyme with phosphoribosylaminoimidazole carboxylase activity, metal binding, and ATP binding. The protein belongs to the PurE and ATP-grasp superfamilies and localizes to the cytoplasm and cytosol. In Saccharomyces cerevisiae, ADE2 is associated with purine base metabolism and salvage, adenosine and inosine transport, and histidine, tetrahydrofolate, and melibiose metabolism. It has also been linked to plasmid maintenance, DNA protection, tRNA modification, nitrogen fixation, phosphatidylserine anabolism, amyloid fibril formation, and epithelial cell-cell adhesion. Phenotypic associations include abnormal colony color, auxotrophy, altered nitrogen source utilization, decreased chronological lifespan and vegetative growth rate, reduced competitive fitness, and altered chemical resistance. Studies of related genes in other species link the ADE2 family to loss of pathogenicity.