BUB3 — Saccharomyces cerevisiae S288c

Summary

YOR026W encodes a WD40-repeat-containing protein that binds ubiquitin and RNA. The gene product localises to the kinetochore, nuclear periphery, nucleoplasm, and the Bub1-Bub3 complex, and is associated with mitotic and meiotic chromosome segregation, spindle checkpoint signalling, MCC assembly, centromere localisation, nuclear movement, actin polymerisation, and translation initiation. YOR026W has been linked to abnormal chromosome segregation, premature anaphase progression, decreased mitotic recombination, increased cell size, decreased respiratory growth, increased oxidative stress resistance, altered metal and toxin resistance, decreased chronological lifespan, and absent sporulation. Studies of related genes in other species connect the family to nuclear pore complex function.