EXO1 — Saccharomyces cerevisiae S288c

Summary

YOR033C, also known as EXO1 in Saccharomyces cerevisiae S288c, encodes a protein with 5'-3' DNA exonuclease activity, double-stranded DNA 5'-3' DNA exonuclease activity, 5' flap endonuclease activity, and dsDNA binding. The protein belongs to the XPG/Rad2 family and contains PIN-like and H3TH domains. This gene is associated with multiple DNA repair pathways including double-strand break repair, nucleotide excision repair, base excision repair, mismatch repair, and non-homologous end joining. It is linked to telomere organization and assembly, meiotic DNA double-strand break processing, gene conversion, and maintenance of DNA trinucleotide repeats. The protein localizes to the nucleus, nucleolus, nucleoplasm, and sites of double-strand breaks. Phenotypic associations include increased mutation frequency, decreased UV resistance, decreased spore germination, altered cell size, and abnormal vacuolar morphology. The gene is also associated with oxidative stress. Related genes in other species show sequence similarity to FEN1 and exo1.