AUS1 — Saccharomyces cerevisiae S288c

Summary

YOR011W, also known as AUS1, is a gene on chromosome XV of Saccharomyces cerevisiae S288c that encodes an ABC-type xenobiotic transporter with ATP-coupled transmembrane transporter activity and ATP hydrolase activity. The protein belongs to the ABCG_PDR and PDR_CDR_ABC domain families. AUS1 is associated with sterol import, intracellular sterol transport, and sterol homeostasis, as well as cellular response to xenobiotic stimulus, xenobiotic detoxification by transmembrane export across the plasma membrane, and response to antibiotic. It is linked to ergosterol anabolism, lipid oxidation, and quorum sensing. The gene is associated with decreased heat sensitivity, decreased starvation resistance, decreased chemical compound accumulation, and increased competitive fitness. Studies of related genes in other species connect the family to additional ABC transporter domains.