NGL1 — Saccharomyces cerevisiae S288c

Summary

YOL042W in Saccharomyces cerevisiae S288c encodes a protein with poly(A)-specific RNase and 3'-5' exoribonuclease activities, and is a component of the CCR4-NOT complex and P bodies. The gene is associated with regulation of mRNA metabolism and stability, nuclear RNA surveillance, posttranscriptional gene expression, and negative regulation of gene expression. It has been linked to mitochondrial biogenesis, histogenesis, and the response to host. Phenotypic associations include abnormal mitochondrial genome maintenance, decreased respiratory growth rate, increased chronological lifespan, altered chemical compound accumulation, increased heat sensitivity, and both increased and decreased competitive fitness. The gene is also associated with oxidative stress and vacuolar morphology. Studies of related genes in other species link the family to 3'-5' exoribonuclease activity (EC 3.1.13.4).