ADH1 — Saccharomyces cerevisiae S288c

Summary

YOL086C in Saccharomyces cerevisiae S288c encodes an aldo-keto reductase with NAD activity and zinc binding capability, belonging to the alcohol dehydrogenase zinc-binding domain family. The gene is associated with diverse metabolic processes including ethanol fermentation, the pentose-phosphate shunt, the TCA cycle, mixed acid fermentation, and biosynthesis of lutein, butanediol, ethylene, and glycine. It has been linked to response to testosterone, excretion, biofilm formation, biotin transport, and reactive oxygen species metabolism. The protein localizes to the cytoplasm, mitochondrial lumen, and fungal biofilm matrix. Phenotypic associations connect YOL086C to altered fermentative and respiratory metabolism, increased chronological and replicative lifespan, changes in oxidative stress resistance, thermotolerance, metal and toxin resistance, UV sensitivity, cell size, colony appearance, and vegetative growth. The gene is also associated with heterosis, glucose content, biomass yield, oxidative stress, and acid sensitivity.