HMI1 — Saccharomyces cerevisiae S288c

Summary

YOL095C (HMI1) on chromosome XV of Saccharomyces cerevisiae S288c encodes a 3'-5' DNA helicase with ATP hydrolase, DNA binding and ATP binding activities. The gene is associated with mitochondrial DNA metabolism and packaging, oxidative phosphorylation, the MAPK cascade, regulation of non-homologous end joining, DNA recombinase assembly, resolution of recombination intermediates, and regulation of sister chromatid cohesion. It has been connected to invasive and filamentous growth, response to caffeine and ionizing radiation, and RNA processing. The product localizes to the nucleus. Phenotypic associations include decreased invasive growth, increased mitophagy, petite formation, abnormal or absent mitochondrial genome maintenance, altered stress resistance, increased biofilm formation, and changes in vegetative growth, competitive fitness, and sensitivity to heat, hyperosmotic stress, and chemicals. Studies of related genes in other species link the family to DNA helicase activity (EC 5.6.2.4).