NTG2 — Saccharomyces cerevisiae S288c

Summary

YOL043C, also known as NTG2, on chromosome XV of Saccharomyces cerevisiae S288c encodes a DNA glycosylase with 5-hmU, 5-foU, 8-oxoG and oxidized pyrimidine and purine base lesion DNA N-glycosylase activities, as well as AP site-DNA 5'-phosphomonoester-lyase and AP deoxyendoribonuclease activities, and binds 4Fe-4S clusters and metals. The gene is associated with base-excision repair, AP site formation, mitochondrial DNA repair, DNA double-strand break processing, and DNA modification. It is linked to response to freezing, regulation of carbohydrate metabolism, glucose effect, maltose metabolism, mycose catabolism, galactose metabolism, ubiquinone anabolism, autophagy, ascospore wall assembly, fungal-type cell wall assembly, regulation of cell division, regulation of phosphorylation, and protein oxidation. The product localizes to the mitochondrial lumen, mitochondria, and nucleus. The gene is associated with increased mutation frequency, decreased chromosome/plasmid maintenance, decreased starvation resistance, decreased metal resistance, abnormal chemical compound accumulation, increased and decreased competitive fitness, and increased and decreased resistance to chemicals.