GAL11 — Saccharomyces cerevisiae S288c

Summary

YOL051W in Saccharomyces cerevisiae S288c encodes a transcriptional co-regulator that is a component of the Mediator complex, specifically belonging to the MED15/GAL11 family. The gene is associated with a wide range of biological processes, including transcription by RNA polymerase II, regulation of fatty acid beta-oxidation, phospholipid and inositol anabolism, oxidative phosphorylation, sporulation, fermentation, and response to xenobiotic stimuli. It has been linked to numerous phenotypes, such as altered resistance to acid, osmotic, and oxidative stress, changes in respiratory and vegetative growth, decreased sporulation, abnormal silencing, and increased mitophagy. Additionally, YOL051W is connected to traits including light sensitivity, acid sensitivity, and oxidative stress. Studies of related genes in other species further link this family to transcriptional regulation.