TAT2 — Saccharomyces cerevisiae S288c

Summary

YOL020W in Saccharomyces cerevisiae S288c encodes an amino acid permease, a transmembrane transporter with activity for L-proline, L-arginine, L-lysine, and other amino acids. The protein localises to the plasma membrane, cell tip, Golgi membrane, and extracellular vesicles. It is associated with a wide range of biological processes including amino acid import and transport, proline anabolism, gluconeogenesis, regulation of endocytosis, and response to SDS. The gene has been linked to traits such as nitrogen content, potassium uptake, phosphate content, acid sensitivity, and oxidative stress. Phenotypic associations include decreased cold sensitivity, increased telomere length, altered replicative lifespan, and changes in competitive fitness and vegetative growth rate. Studies of related genes in other species, such as GAP2, GAP4, and AGP1, further connect the family to general amino acid transport.