TOP1 — Saccharomyces cerevisiae S288c

Summary

YOL006C in Saccharomyces cerevisiae S288c encodes a type I topoisomerase with DNA-binding and topoisomerase IB activity, localizing to the nucleus, nucleoplasm, chromatin, nucleolus, and cytosol. This gene is associated with numerous DNA-related processes including bypass DNA synthesis, DNA recombination, base excision repair, postreplication repair, gene conversion, R-loop processing, and spindle assembly checkpoint. It is linked to cell killing, metaphase, nuclear division, regulation of sumoylation, and epithelial-to-mesenchymal transition. Phenotypically, YOL006C is connected to increased gamma ray resistance, decreased UV resistance, altered chromosome maintenance, increased mutation frequency, decreased sporulation, increased chronological lifespan, and altered stress responses including oxidative stress resistance and metal resistance. Studies of related genes in other species link the family to DNA topoisomerase activity (EC 5.6.2.1) and reduced virulence.