ACC1 — Saccharomyces cerevisiae S288c

Summary

YNR016C, also known as ACC1, on chromosome XIV of Saccharomyces cerevisiae S288c, encodes a protein with acetyl-CoA carboxylase, biotin carboxylase, pyruvate carboxylase, urea carboxylase, allophanate hydrolase, and hydrolase activities, and which binds ATP and metal ions. The gene is associated with malonyl-CoA anabolism, fatty acid elongation, acetate metabolism, mRNA transport, fatty acid metabolism, fatty acid anabolism, protein phosphorylation, lipogenesis, lipid homeostasis, carnitine anabolism, NO storage, mitotic nuclear membrane biogenesis, long-chain fatty acid anabolism, RNA transport, very-long-chain fatty acid anabolism, urea breakdown, phosphatidylethanolamine anabolism, and rRNA processing. It localises to the fungal-type vacuole membrane, mitochondria, cytoplasm, and cytosol. The gene is linked to herbicide sensitivity and phenotypes including inviability, altered protein activity, increased autophagy, altered chemical compound accumulation, increased RNA accumulation, abnormal chromosome/plasmid maintenance, heat sensitivity, haploproficiency, haploinsufficiency, decreased competitive fitness, and decreased chemical resistance. Studies of related genes in other species connect the family to oxidative stress.