PHO80 — Saccharomyces cerevisiae S288c

Summary

YOL001W (PHO80, preg) on chromosome XV of Saccharomyces cerevisiae S288c encodes a cyclin-dependent protein serine/threonine kinase regulator with protein kinase binding activity, belonging to the PHO80-like cyclin family. The gene is associated with phosphate metabolism, polyphosphate anabolism, Pi homeostasis, iron transport, lipid metabolism, glycogenolysis, vacuole inheritance, cell cycle control, G2 phase, morphogenesis, response to stress, and response to trehalose. It localises to the CDK holoenzyme, mitotic spindle pole body, cell division site, cytosol, and nucleus. Associations include phosphate and sodium content, potassium uptake, calcium and acid sensitivity, oxidative stress, and salt tolerance. Phenotypic connections include decreased alkaline pH resistance, altered telomere length, reduced replicative lifespan, increased stress and metal resistance, decreased desiccation and hyperosmotic stress resistance, and altered fermentative and respiratory growth.