TOF1 — Saccharomyces cerevisiae S288c

Summary

YNL273W (TOF1) on chromosome XIV of Saccharomyces cerevisiae S288c encodes a DNA-binding protein that belongs to the Timeless family, containing a Timeless_N domain. The gene is associated with DNA replication and damage checkpoints, sister chromatid cohesion, telomere capping and maintenance, telomeric silencing, DNA replication termination, and responses to UV, UV-A, hydroxyurea, and methyl methanesulfonate. It is also linked to base excision repair, circadian rhythm, maintenance of DNA repeat elements, anaphase, and oxidative stress. The protein localizes to the cytosol and the FPC complex. Phenotypic associations include abnormal telomere length, increased S-phase duration, abnormal spindle morphology, increased mitotic recombination and mutation frequency, decreased UV resistance, altered heat sensitivity, decreased competitive fitness, and abnormal vacuolar morphology. Related genes in other species link the family to replication fork stability.