PRP2 — Saccharomyces cerevisiae S288c

Summary

YNR011C in Saccharomyces cerevisiae S288c encodes a DEAD/DEAH-box helicase with 3'-5' RNA helicase activity, ATP binding, and dsRNA binding, and is associated with the spliceosome complex, nucleolus, and chromatin. This gene is linked to cell cycle DNA replication, cell cycle checkpoint, mRNA processing, telomere maintenance, and glycolytic fermentation. It is associated with primary growth, organogenesis, sex determination, and response to peptide. Associations include protein content, oxidative stress, and phenotypes such as increased cold sensitivity, heat sensitivity, and altered toxin resistance. The gene is also linked to sporulation absence and inviability. Related genes in other species connect the family to RNA processing and ATP-dependent helicase functions.