URE2 — Saccharomyces cerevisiae S288c

Summary

YNL229C (URE2) on chromosome XIV of Saccharomyces cerevisiae S288c encodes a protein with glutathione peroxidase, glutathione transferase, and transcription corepressor activities, and it also binds phosphoproteins. The protein belongs to the Ure2 and glutathione S-transferase families. URE2 is associated with nitrogen catabolite repression, amino acid import, TOR signaling, the MAPK cascade, pseudohyphal growth, sexual sporulation, amyloid fibril formation, and responses to nutrients and rapamycin. It is linked to traits including nitrogen and amino acid content, biomass yield, phosphate content, calcium sensitivity, and oxidative stress. Phenotypic associations include abnormal autophagy, increased fermentative metabolism, decreased phosphorus utilization, altered pseudohyphal and filamentous growth, delayed G1 cell cycle progression, and changes in stress resistance, metal resistance, UV resistance, replicative lifespan, biofilm formation, and cell size. The protein localizes to the cytoplasm.