ZWF1 — Saccharomyces cerevisiae S288c

Summary

YNL241C encodes a glucose 1-dehydrogenase (NADP+) activity and is also annotated as G6PDH, with NADP binding capability. The protein belongs to the G6P_DH family and is localized to the cytosol. This gene is associated with the pentose-phosphate shunt, TCA cycle, carbohydrate metabolism, inositol breakdown, fatty acid and terpene anabolism, D-xylose fermentation, and responses to stress and diamide. It has been linked to traits including biomass yield, protein content, oxygen sensitivity, and oxidative stress. Phenotypic associations include increased autophagy, decreased chronological lifespan, altered stress resistance (both increased and decreased oxidative stress resistance), decreased competitive fitness, and abnormal vacuolar morphology. Studies of related genes in other species connect the family to glucose-6-phosphate dehydrogenase (EC 1.1.1.49) activity.