RAD50 — Saccharomyces cerevisiae S288c

Summary

YNL250W (RAD50) in Saccharomyces cerevisiae S288c encodes a protein with DNA helicase activity, ATP hydrolase activity, and binding to double-stranded and single-stranded telomeric DNA, G-DNA, and metal ions. It is a component of the MRN complex and localizes to chromatin, condensed nuclear chromosomes, and sites of double-strand breaks. The gene is associated with DNA recombination, homologous and non-homologous end joining, base excision and mismatch repair, postreplication repair, transposition, gene conversion, strand invasion, mitochondrial DNA replication, bypass DNA synthesis, replicative senescence, prophase, sumoylation, and cell cycle checkpoint responses. It is linked to decreased telomere length, increased mutation frequency and transposable element transposition, reduced spore germination, sporulation, mitotic recombination, fermentative growth, and resistance to X-rays, gamma rays, UV, oxidative stress, hyperosmotic stress, acid pH, heat, and enzymatic treatment, as well as increased cell size, innate thermotolerance, and colony sectoring.