RAP1 — Saccharomyces cerevisiae S288c

Summary

YNL216W in Saccharomyces cerevisiae S288c encodes the Rap1 protein, a DNA-binding factor containing Myb, BRCT, and Rap1-specific domains. Rap1 is associated with telomere organization and maintenance, telomeric silencing, and regulation of telomere capping. It is linked to cell cycle checkpoint control, rRNA transcription, chromatin decompaction, and cAMP metabolism. The gene is associated with oxidative stress and with numerous phenotypes including abnormal telomere length (both increased and decreased), increased silencing, increased nucleolus size, decreased replicative lifespan, decreased viability, decreased UV resistance, decreased vegetative growth and competitive fitness, altered chemical and metal resistance, and altered toxin resistance. Rap1 is also associated with responses to dsDNA, histidine, and pH regulation, as well as with plasmid partitioning and the stringent response.