CRZ1 — Saccharomyces cerevisiae S288c

Summary

YNL027W, also known as CRZ1, is a gene on chromosome XIV of Saccharomyces cerevisiae S288c that encodes a C2H2-type zinc-finger DNA-binding transcription factor with both activator and repressor activity, and which also binds 14-3-3 proteins. CRZ1 is associated with calcium signaling, phosphorus metabolism, regulation of cell growth, endomembrane organization, and responses to pH, cold, and acid chemical stress. It has been linked to the positive regulation of antisense RNA transcription and septum digestion after cytokinesis, as well as to the regulation of apoptotic processes and cell pH elevation. The gene is associated with traits including calcium sensitivity, turgor pressure, and oxidative stress, and with phenotypes such as decreased resistance to ionic, alkaline pH, hyperosmotic, and oxidative stress, increased mutation and pheromone sensitivity, and altered chronological lifespan and competitive fitness. Studies of related genes in other species link the family to calcineurin-mediated signaling and loss of pathogenicity.