DCP2 — Saccharomyces cerevisiae S288c

Summary

YNL118C (DCP2) in Saccharomyces cerevisiae S288c encodes a NUDIX hydrolase domain-containing protein with m(7)GpppN-mRNA hydrolase activity, catalysing mRNA cap decapping. The gene is associated with mRNA and long non-coding RNA breakdown, RNA decapping (both deadenylation-dependent and -independent), stress granule assembly, spore germination, retrotransposition, gene silencing by miRNA, translational attenuation, and positive regulation of transcription initiation by RNA polymerase II. The Dcp1-Dcp2 complex localises to P-bodies, stress granules, the cytoplasm, cytosol, and nucleus. Associations with oxidative stress, increased apoptosis, increased nucleolus size, increased transposable element transposition, abnormal cellular morphology, increased RNA and protein accumulation, increased colony sectoring, decreased starvation resistance, altered chemical and toxin resistance, decreased competitive fitness, and inviability or haploinsufficiency have been observed. Studies of related genes in other species link the family to general hydrolase activity (EC 3.-.-.-).