RAS2 — Saccharomyces cerevisiae S288c

Summary

YNL098C (RAS2) on chromosome XIV of Saccharomyces cerevisiae S288c encodes a small GTPase of the Ras-type family with GTPase activity and the ability to bind GTP, GDP, CTP and UTP. The gene is associated with regulation of growth, the MAPK cascade, protein phosphorylation, response to glucose and nutrient levels, replicative senescence, programmed cell death, glycogen metabolism, amino acid import, vitamin metabolism, and the spindle checkpoint. It localises to the plasma membrane, division septum, cell cortex of cell tips, and cortical dynamic polarity patches. RAS2 has been linked to biomass yield, protein content, amino acid content, oxidative stress, and light sensitivity. Phenotypic associations include increased pseudohyphal and filamentous growth, altered autophagy and pexophagy, changes in cell cycle progression, sporulation defects, and altered stress resistance and viability. Studies of related genes in other species have connected the family to reduced virulence.