POL1 — Saccharomyces cerevisiae S288c

Summary

YNL102W (POL1) in Saccharomyces cerevisiae S288c encodes a protein with DNA-directed DNA polymerase activity, 3'-5' DNA exonuclease activity, and DNA replication origin binding activity. It also binds 4Fe-4S clusters, zinc, single-stranded DNA, and chromatin. The gene is associated with DNA replication initiation, leading and lagging strand elongation, Okazaki fragment RNA removal, DNA repair pathways including base-excision and nucleotide-excision repair, gene conversion, telomeric silencing, and the DNA damage response. It localizes to the alpha, delta, and zeta DNA polymerase complexes, the nuclear replication fork, telomeric regions, and sites of double-strand breaks. Phenotypic associations include increased telomere length, increased mitotic and meiotic recombination, increased mutation frequency, decreased replicative lifespan, cell cycle arrest in S and G1 phases, decreased sporulation and vegetative growth, increased heat sensitivity, and altered chemical resistance.