TOP2 — Saccharomyces cerevisiae S288c

Summary

YNL088W in Saccharomyces cerevisiae S288c encodes a DNA topoisomerase type II enzyme with ATP hydrolase activity, DNA binding, identical protein binding, and metal binding functions. This gene is associated with chromosome biorientation, condensation, spindle assembly and checkpoint control, DNA topological change, replication fork progression beyond termination sites, strand invasion, resolution of meiotic recombination intermediates, chromatin remodeling at centromeres, rDNA packaging, mitotic spindle positioning, and regulation of mitotic recombination. It localizes to the nucleus, chromatin, euchromatin, the chromosome centromeric core domain, and the TER. Phenotypic associations include increased thermotolerance, decreased acquired and innate thermotolerance, increased heat sensitivity, delayed G2/M phase transition, decreased viability, increased mutation frequency, decreased protein accumulation, altered chemical resistance, and decreased vegetative growth rate. Studies of related genes in other species link the family to DNA topoisomerase type II activity (EC 5.6.2.2).