HDA1 — Saccharomyces cerevisiae S288c

Summary

YNL021W in Saccharomyces cerevisiae S288c encodes a histone deacetylase with activity against multiple histone H3 and H4 lysine residues, including H3-K9, H3-K14, H4-K5, H4-K8, H4-K12, and H4-K16, and also possesses chromatin-binding and identical protein-binding capabilities. The gene is associated with flocculation, filamentous growth in response to pH, epigenetic downregulation of gene expression, heterochromatin island assembly, RNA stabilization, nucleocytoplasmic transport, DNA damage response, and protein acetylation. It localizes to several chromatin-modifying complexes, including the HDA1, Rpd3S, SHREC, SET3C, and Clr6-LE complexes, as well as euchromatin and heterochromatin islands. Phenotypic associations include increased flocculation and silencing, altered stress resistance, abnormal sporulation, and effects on lifespan and vegetative growth. Studies of related genes in other species link the family to histone deacetylase activity (EC 3.5.1.98).