GAS1 — Saccharomyces cerevisiae S288c

Summary

YMR307W in Saccharomyces cerevisiae S288c encodes a 1,3-beta-glucanosyltransferase, an enzyme with glucanosyltransferase activity. This gene is associated with cell wall assembly and biogenesis, protein mannosylation, and glucan and chitin anabolism. The encoded protein localizes to sites of polarized growth, including the cell septum edging, cellular bud scar and membrane, and the external side of the plasma membrane. YMR307W is linked to traits such as mannose, beta-glucan, and polysaccharide content, as well as salt, acid, and oxidative stress sensitivity. Phenotypic associations include abnormal cell wall morphology, increased chitin deposition, altered budding pattern, decreased replicative lifespan, and reduced resistance to hyperosmotic stress, enzymatic treatment, and oxidative stress. The gene is also associated with increased mating response, sporulation efficiency, and killer toxin resistance, alongside absent filamentous and pseudohyphal growth. Related glucanosyltransferase family members in other species are linked to reduced virulence.