SAS2 — Saccharomyces cerevisiae S288c

Summary

YMR127C in Saccharomyces cerevisiae S288c encodes a histone acetyltransferase with activity on multiple histone residues, including H3K4, H3K14, H4K12, and also functions as a peptide 2-hydroxyisobutyryltransferase, butyryltransferase, and crotonyltransferase. The protein belongs to the MYST family of histone acetyltransferases and is a component of the NuA3a, Piccolo, and TIP60 histone acetyltransferase complexes. It is associated with chromatin binding, transcriptional co-regulation, and zinc binding. The gene is linked to the regulation of chromosome organization, positive regulation of triglyceride biosynthesis, heterochromatin formation and boundary maintenance, DNA damage response, DNA-templated transcription elongation, RNA polymerase III assembly, and macroautophagy. Associations with traits include oxidative stress, and phenotypes include altered silencing, increased or decreased chronological and replicative lifespan, altered competitive fitness, and abnormal vacuolar morphology. Related genes in other species link the family to histone acetylation and cell viability.