MRE11 — Saccharomyces cerevisiae S288c

Summary

YMR224C, the MRE11 gene on chromosome XIII of Saccharomyces cerevisiae S288c, encodes a protein with double-stranded and single-stranded DNA 3'-5' exonuclease activity, single-stranded DNA endodeoxyribonuclease activity, DNA end binding, and nuclease activity. It is a component of the MRN complex and localizes to chromosome telomeric repeat regions and sites of double-strand breaks. MRE11 is associated with recombinational repair, non-homologous end joining, base excision repair, homologous recombination, and mitochondrial double-strand break repair. It has been linked to spore wall biogenesis, zygotene, pachytene, replicative senescence, regulation of meristem development, cell killing, spindle assembly checkpoint, DNA metabolism, transposition, chromatin organization, and sumoylation. Associations with traits include potassium concentration and oxidative stress. Phenotypic associations include abnormal spore wall formation, increased apoptosis, decreased gamma ray resistance, decreased telomere length, decreased sporulation, increased mutation frequency, and altered replicative and chronological lifespan.