CLN1 — Saccharomyces cerevisiae S288c

Summary

YMR199W (CLN1) on chromosome XIII of Saccharomyces cerevisiae S288c encodes a protein with cyclin-dependent protein serine/threonine kinase regulator activity and protein kinase activity. CLN1 is associated with cell cycle control, particularly the G1/S phase transition, and with DNA damage checkpoint, MAPK cascade, and pheromone response. It is linked to pseudohyphal and invasive growth, cell adhesion, and response to nutrients and peptides. The gene is associated with traits including oxidative stress and phenotypes such as decreased invasive and pseudohyphal growth, abnormal cell cycle progression, altered sporulation efficiency, decreased stress and starvation resistance, and changes in competitive fitness and vegetative growth rate. The protein localizes to the CDK holoenzyme, cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to reduced virulence.