HSC82 — Saccharomyces cerevisiae S288c

Summary

YMR186W, also known as HSC82 or HSP90, encodes an ATP-dependent protein folding chaperone in Saccharomyces cerevisiae S288c on chromosome XIII. The product belongs to the Hsp90 family and possesses ATP hydrolase activity, unfolded protein binding, and identical protein binding. HSC82 is associated with programmed cell death, including the intrinsic apoptotic pathway, and regulation of signal transduction. It is linked to responses to abiotic stimuli such as thermal stimulus, oxygen levels, and hormones, as well as unsaturated fatty acid metabolism and positive regulation of telomere maintenance via telomerase. The protein localizes to the perinuclear region of the cytoplasm, mitochondria, plasma membrane, and extracellular vesicles. Associations with germination rate, salt sensitivity, and oxidative stress have been noted, along with phenotypes including increased heat sensitivity, altered competitive fitness, and decreased freeze-thaw resistance.