PAH1 — Saccharomyces cerevisiae S288c

Summary

YMR165C in Saccharomyces cerevisiae S288c encodes a phosphatidate phosphatase enzyme, a member of the lipin family characterized by Lipin_N, LNS2, and HAD-like domains. This gene is associated with numerous lipid-related processes including triglyceride and phospholipid anabolism, diacylglycerol anabolism, lipogenesis, and phosphatidic acid metabolism. It is linked to nuclear membrane biogenesis, vacuole fusion, adiposome formation, and regulation of phosphorylation. The protein localizes to both the cytosol and nucleus. Phenotypic associations include abnormal endoplasmic reticulum, nuclear, and vacuolar morphology, decreased lipid particle morphology, reduced nucleolus size, increased heat sensitivity, decreased desiccation resistance, impaired carbon source utilization, decreased competitive fitness, and reduced vegetative growth rate. The gene is also associated with oxidative stress and altered chemical compound accumulation.