MSN2 — Saccharomyces cerevisiae S288c

Summary

YMR037C in Saccharomyces cerevisiae S288c encodes a C2H2-type zinc-finger DNA-binding transcription factor that localises to the nucleus, cytoplasm and chromatin, and is a component of the Tec1p-Ste12p-Dig1p and Ste12p-Dig1p-Dig2p complexes. The gene is associated with diverse biological processes including proline metabolism, cellular senescence, regulation of autophagy, response to ethanol, glucose and oxidative stress, TOR signalling, the MAPK cascade, calcium signalling, deubiquitination, mRNA metabolism, malate secretion, and ethanol fermentation. It is linked to numerous traits and phenotypes such as altered glucose content, calcium and light sensitivity, increased or decreased fermentative growth rate, altered freeze-thaw resistance, changes in filamentous and invasive growth, decreased replicative and chronological lifespan, altered oxidative stress resistance, and increased competitive fitness. Studies of related genes in other species link the family to reduced virulence.