MCM1 — Saccharomyces cerevisiae S288c

Summary

YMR043W (MCM1) on Saccharomyces cerevisiae chromosome XIII encodes a MADS-box transcription factor with DNA-binding and protein dimerization activity. It is associated with mating type determination, pseudohyphal growth regulation, cell cycle control, plasmid maintenance, arginine metabolism, ribosome biogenesis, and morphogenesis. The protein localizes to chromatin and the nucleus. MCM1 is linked to numerous phenotypes including abnormal mating response, decreased pheromone-induced cell cycle arrest, sterility, decreased budding index, abnormal spindle and nuclear morphology, decreased alkaline pH resistance, increased heat sensitivity, decreased replicative lifespan, and abnormal chromosome/plasmid maintenance. It is also associated with amino acid content and oxidative stress traits.