MIH1 — Saccharomyces cerevisiae S288c

Summary

YMR036C in Saccharomyces cerevisiae S288c encodes a protein with protein tyrosine phosphatase activity and broader protein phosphatase activity. This gene is associated with cell cycle regulation, including the septin checkpoint, mitotic exit, and positive regulation of the G2/M transition of the meiotic cell cycle, as well as cell size control. It has been linked to cAMP metabolism, regulation of adenylyl cyclase and CDK activity, and responses to ethylene and miconazole. The encoded protein localizes to the cytoplasm, cytosol, and nucleus. Phenotypic associations include increased cell size, altered cell cycle progression in G2 phase, decreased replicative lifespan, and altered stress resistance and chemical resistance. The gene is also connected to traits such as cell membrane stability, protein content, and oxidative stress. Studies of related genes in other species link the family to protein tyrosine phosphatase activity (EC 3.1.3.48) and, more distantly, to root width and leaf shape.