NAB6 — Saccharomyces cerevisiae S288c

Summary

YML117W (NAB6) in Saccharomyces cerevisiae S288c on chromosome XIII encodes an RNA-binding protein with poly(U) binding and mRNA binding activities. The gene is associated with mRNA destabilization and stabilization, the MAPK cascade, RNA metabolism, nuclear RNA surveillance, transcriptional attenuation, ribosome biogenesis, and cellular response to nutrient levels. Its product localizes to the cytoplasm, cytosol, and stress granules. NAB6 is linked to numerous phenotypes including decreased resistance to gamma rays, oxidative stress, desiccation, heat, and toxins, as well as abnormal vegetative growth, decreased competitive fitness, and increased resistance to enzymatic treatment and certain chemicals. Studies of related genes in other species connect the family to additional cellular processes.