PHO84 — Saccharomyces cerevisiae S288c

Summary

YML123C in Saccharomyces cerevisiae S288c encodes a transmembrane transporter protein with glycerol-3-phosphate, glycerophosphodiester, phosphate, and proton:sugar symporter activities, belonging to the MFS sugar transporter-like family. This gene is associated with phosphorus and polyphosphate metabolism, intracellular sterol transport, retrograde response, calcium signaling, ethanol fermentation, response to aluminum and manganese, and RNA stabilization. It localizes to the cell periphery, plasmalemma, ER membrane, Golgi complex, and fungal-type vacuole. YML123C is linked to traits including phosphorus and copper concentration, potassium uptake, calcium sensitivity, and oxidative stress. Phenotypic associations include altered vegetative growth, decreased replicative lifespan, abnormal lipid particle morphology, decreased biofilm formation, and changes in metal resistance, chemical compound accumulation, and nutrient utilization. Related genes in other species connect the family to phosphate transport and signaling.